Endocrine Abstracts

Objective: Maternal and female fetal virilization is subject to exaggerating androgen secretion of pregnancy luteomas which is associated with the protective capacity of placenta safeguard against hormone conversion and presents with variable extent of female pesudohermapharotidism as exposure in critical gestational stage.Patient(s): A nulligravida woman suffering from bilateral hydronephrosis and recurrent acute pyelonephritis caused by bilateral solid...

Insulin resistance is an integral part of the metabolic syndrome. Insulin resistance and metabolic syndrome predisposes to chronic kidney disease. However, the determinants of insulin resistance (measured by the homeostasis model, HOMA-IR) and metabolic syndrome are not known in hemodialysis (HD) patients. Thus, we studied 157 HD patients.Results: The prevalence of metabolic syndrome was 46.5%. Patients with metabolic syndrome had higher HOMA-IR (5.6&#17...

Introduction: Sitosterolemia is a rare lipid disorder characterised by excessive accumulation of phytosterols in the body. There are fewer than 110 cases worldwide, and to our knowledge, there are no reported cases of adult Sitosterolemia from South-East Asia. We report our experience in diagnosing a middle-aged Chinese lady from Singapore with Sitosterolemia.Case Report: A 45-year-old Chinese lady was referred to the Endocrinology clinic in Oct 2022 by ...

Adiposity predisposes to insulin resistance and type II diabetes. Adipose tissue is an active endocrine organ, secreting adipokines with important physiological actions. Adiponectin is a recently discovered adipokine whose levels are, paradoxically, decreased in obesity despite the increase in adipocyte mass. Adiponectin suppresses triglyceride accumulation, increases fatty acid oxidation and activates AMP kinase (AMPK) in skeletal muscle, improving insulin signalling, and it ...

Aldosterone and cortisol coproducing adrenal adenoma is a rare type of primary aldosterone. Previous reports mostly describe single adrenocortical adenomas that simultaneously secrete aldosterone and cortisol. To date, only 7 cases of bilateral adrenocortical adenomas with independent functions of secreting different hormones have been reported in the published English literature. Here, we study an extremely rare case of a left adrenocortical adenoma secreting aldosterone and ...

Objective: The purpose of this study was to describe the outcome after initiation of exenatide therapy and to determine whether the impact of adverse drug reactions on compliance was affected by gender.Methods: A retrospective study was performed of 18 diabetic patients (eight males) that were prescribed exenatide between June 2013 and September 2014. Each included patient received exenatide for ≥1 month. Age, disease course, race, BMI, medical his...

Objective: To investigate the impact of lifestyle intervention on elevated thyroid peroxidase (TPO) antibody levels in outpatients with normal thyroid function.Methods: A retrospective cohort study was performed to observe and evaluate euthyroid patients with excessive TPO antibodies that presented to the authors’ hospital between March 2013 and October 2014 for routine medical examinations. The subjects were randomly divided into the lifestyle inte...

Introduction: We describe a novel case of familial congenital aniridia in a Caucasian woman with associated insulin requiring diabetes mellitus. This human combination has been described in Asian families in association with a heterozygous Paired Box 6 (PAX6) mutation (1) with subsequent evidence supporting that the mutation in this transcription factor causes decreased Proconvertase 1/3 function in the pancreas and a high proinsulin to insulin ratio (2). Our case does not hav...

Urocortin 3 is a CRF-related ligand highly specific for the Corticotropin-Releasing Factor Receptor Type 2 (CRFR2). CRFR2 is implicated in the regulation of stress-related behaviours and the neuroendocrine response to stressors. Close anatomical association between major Urocortin 3 terminal fields and CRFR2 in the limbic system and hypothalamus indicate this system is well placed to be involved in modulating of the physiological stress response. Transgenic mice ubiquitously o...

Aims: Different guidelines of Thyroid Imaging, Reporting, and Data System (TI-RADS) have been published to determine whether FNAC is required. Most of the guidelines recommended observation for nodules less than one centimeter and FNAC for nodule larger than two centimeters. In this study, we focus on the management of nodules size between one and two centimeters. We aim to evaluate the different guidelines on the treatment of thyroid nodules with the computer-aided detection ...